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77 patients had intracerebral hemorrhage(46%fatal)and 44 had subdural hemorrhage(20%fatal).The prothrombin time ratio(PTR)was the dominant risk factor for intracranial hemorrhage.For each 0.5 increase in PTR over the entire range,the risk for intracerebral hemorrhage doubled(odds ratio,2.1: 95%CI,1.4 to 2.9).For subdural hemorrhage,the risk was unchanged over the PTR range from 1.0 to 2.0 but rose dramatically above the PTR of 2.0 (approximate international normalized ratio,4.0).Age was the only other significant5t independent risk factor for subdural hemorrhage(odds ratio, 2.0 per decade;CI;1.0 to 1.6)after controlling for PTR and the two other independent risk factors:history of cerebrovascular disease(odds ratio,3. 1;CI,1.7 to 5.6)and presence of a prosthetic heart valve(odds ratio,2.8: CI,1.3 to 5.8).The results emphasize the importance of maintaining the prothrombin time ratios under 2.0 and the need for especially careful use of warfarin in the elderly. |
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anticoagulant,complications of
anticoagulant,treatment
anticoagulant,treatment in CVD
coumarin
epidemiology of neurology
head injury
intracerebral hemorrhage
intracerebral hemorrhage,volume
intracranial hemorrhage
mortality
old age,neurology of
prothrombin time
prothrombin time,prolonged
risk factors
subdural hematoma
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